Unraveling massive coding and non coding transcriptome dysregulation in T-PLL

Developement of better T-PLL treatment requires identifying molecular vulnerabilities and gaining a deeper understanding of the disease’s heterogeneity. By RNA-seq profiling of T-PLL samples alongside CD4+ cells from healthy donors, we were able to document gene expression changes and pathway disruptions in malignant cells.

Additionally, we discovered significant alterations in the expression of non-coding, antisense, and circular RNAs in T-PLL. This expands current knowledge on the most dysregulated genes and pathways in malignant cells and highlights in non-coding RNAs and circRNAs aberrant expression in T-PLL and in subsets carrying specific driver variants.