Shewanella algae promotes colorectal adenoma development by inducing ferroptosis in macrophages

Furthermore, the expression of key ferroptosis suppressors, including glutathione peroxidase 4 (Gpx4) and solute carrier family 7 member 11 (Slc7a11), was significantly downregulated. These pathological changes were effectively reversed upon treatment with ferrostatin-1 (Fer-1), a specific inhibitor of ferroptosis. In vitro experiments corroborated the in vivo findings, demonstrating consistent activation of ferroptotic pathways in macrophages.

Collectively, these results suggest that S. algae may promote the progression of colorectal adenomas by inducting ferroptosis in both colonic tissues and macrophages. Therefore, therapeutic strategies targeting ferroptosis may offer a promising approach for managing high-risk individuals infected with S. algae, potentially improving clinical outcomes and quality of life.