Omics · study · 2026
Transcriptomic profiling of lead-induced neurotoxicity in differentiated SH-SY5Y cells
Listed in NCBI GEO
Lead is a persistent environmental neurotoxicant that can disrupt neuronal homeostasis through oxidative stress, mitochondrial dysfunction, and inflammatory signaling.
Description
This study generated bulk RNA-sequencing data to characterize transcriptomic responses to sub-lethal lead exposure in differentiated human SH-SY5Y neuroblastoma cells. The dataset includes six independent lead-treated biological replicates and six untreated control biological replicates.
These data provide a resource for investigating molecular pathways, regulatory networks, and potential biomarkers associated with lead-induced neurotoxicity.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE343nnn/GSE343164 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE343164 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1510597 ncbi.nlm.nih.gov/bioproject/PRJNA1510597 ↗
project · from NCBI GEO
- PubMed 42651197 pubmed.ncbi.nlm.nih.gov/42651197 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE343164 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |