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Omics · study · 2026

Network analysis of normal colon organoids exposed to metformin reveals likely regulatory role for colorectal cancer genome-wide association study candidate genes

Listed in NCBI GEO

Here we aimed to define the effects of a three-day, 24-hour repeated dose exposure of metformin (90um) of colon epithelial cell gene expression through RNA-seq and network analysis (WGCNA) of 10 colon organoid lines derived from healthy individuals.

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Expression profiling by high throughput sequencing · Homo sapiens
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Life Sciences
Inferred from text
Cancer 75% · RNA sequencing 65%
Provenance · 1 source records, 9 field assertions
SourceKeyLast seenRaw
NCBI GEOGSE28872412 d agoJSON v1
FieldAssertionExtractorEvidence
access_levelsource · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[disease].local:disease:cancerenrichment · NCBI GEOkeyword-concept-rules@1.0.0title+description (75%)
concepts[field].local:field:life-sciencesmapping · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencingsource · NCBI GEOconnector:ncbi_geo@1.0.0/gdstype
concepts[modality].local:modality:rna-seqenrichment · NCBI GEOkeyword-concept-rules@1.0.0title+description (65%)
concepts[organism].NCBITaxon:9606source · NCBI GEOconnector:ncbi_geo@1.0.0/taxon
descriptionsource · NCBI GEOconnector:ncbi_geo@1.0.0/summary
publication_datesource · NCBI GEOconnector:ncbi_geo@1.0.0
titlesource · NCBI GEOconnector:ncbi_geo@1.0.0/title