Omics · study · 2026
Macrophage TREM2 is a triglyceride-rich lipoprotein receptor that undergoes shedding in prediabetic hepatic steatosis [P630-6]
Listed in NCBI GEO
A mouse model of diet-induced prediabetes and hepatic steatosis was established using male LDL receptor-deficient (Ldlr-/-) mice fed a diabetogenic diet with added cholesterol (36% fat, 36.2% sucrose, 0.15% added cholesterol; DDC).
Description
Compared with littermate controls fed a standard laboratory diet (SLD), mice fed DDC for 22 weeks exhibited elevated plasma sTREM2, APOC3, triglycerides, cholesterol, and free fatty acids, as well as a positive correlation between plasma sTREM2 and APOC3.
Liver bulk RNA sequencing showed increased macrophage and inflammatory signatures and reduced cholesterol biosynthesis signatures consistent with hepatic cholesterol accumulation in this mouse model of prediabetes and hepatic steatosis.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE343nnn/GSE343509 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE343509 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1511675 ncbi.nlm.nih.gov/bioproject/PRJNA1511675 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE343509 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |