Omics · study · 2026
Dietary Interventions Promoting Mutant Uromodulin Clearance as a Therapeutic Strategy in Preclinical Models of Autosomal Dominant Tubulointerstitial Kidney Disease [RNA-seq_WT_R186S_CR]
Listed in NCBI GEO
Missense mutations in UMOD cause autosomal dominant tubulointerstitial kidney disease (ADTKD-UMOD), a prevalent monogenic disorder caused by intracellular accumulation of mutant uromodulin.
Description
We previously showed how stimulation of autophagy through nutrient deprivation promotes the clearance of mutant uromodulin, reducing toxic aggregates and ER stress and alleviating kidney disease. We exposed 8-week old UmodR186S/+ to a 4-week progressive CR compared to ad libitum (AL) feeding in mutant and WT littermates.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE314nnn/GSE314131 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE314131 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1390141 ncbi.nlm.nih.gov/bioproject/PRJNA1390141 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Disease 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE314131 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |