Smad4 binding profiles during a CD8 T cell response

Earlier studies have shown that TGF-β plays a role in promoting T cell exhaustion during the later stages of chronic viral infection. In this dataset we examined the Smad4 binding profile during CD8 T cell responses to chronic lymphocytic choriomeningitis virus (LCMV) infection of mice..

Our findings documenting the striking requirement for Smad4-SKI-SKIL mediated restraint of TGF-β-associated program during the effector phase of the CD8 T cell response have implications for developing immunotherapeutic approaches against chronic viral infections and cancer.