Omics · study · 2026
Transciptomic analysis of lungs from mice with selective expression of hACE2 in ATII and club cells after SARS-CoV-2 infection
Listed in NCBI GEO
To define the contribution of type II alveolar epithelial cells (ATII) and club cells in SARS-CoV-2-induced lung immunopathology and protective immune responses, we generated mice with selective expression of hACE2 in ATII and club cells, respectively.
Description
Our results indicate that SARS-CoV-2 infection elicits a robust immune response dominated by T cell and macrophage activation, primarily driven by infection of ATIIs, with club cells playing a more limited but complementary role.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE307nnn/GSE307428 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307428 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1321665 ncbi.nlm.nih.gov/bioproject/PRJNA1321665 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE307428 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |