Omics · study · 2026
Study on the role and mechanism of AKR1B10 in atopic dermatitis
Listed in NCBI GEO
Atopic dermatitis is a severe skin disorder.
Description
As the core components of the skin barrier, epithelial cells play a critical role in preserving skin barrier function. The function of AKR1B10 in epithelial cells remains poorly defined.
In this dataset, Human Adult low Calcium high Temperature Keratinocytes (HaCat) were used to mimic the pathological microenvironment of atopic dermatitis (AD) in vitro, and mRNA‑sequencing was performed on AKR1B10‑overexpressing (oe) and empty‑vector (ev) control samples.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE345nnn/GSE345259 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE345259 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1519354 ncbi.nlm.nih.gov/bioproject/PRJNA1519354 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Sequencing 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE345259 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |