Differences of gene expression in liver of WT mice, Con A mice and FMT-Con A mice

The gut microbiota serves as a critical link between the external environment and our internal environment, with an inseparable bidirectional relationship between the liver and the gut. Previous research has uncovered a fascinating phenomenon: AIH model mice induced with Con A exhibit a remarkably strong self-healing ability within 48 hours.

Focusing on the post-Con A treatment timepoint. To investigate the effects of fecal microbiota transplantation (FMT) on Con A-induced AIH, we transplanted microbiota from Con A donor mice into recipient mice for 4 weeks prior to Con A challenge. FMT-Con A recipient mice liver showed significantly improve post-Con A treatment, compared to Con A-only mice.