Omics · study · 2026
RNA-seq analysis of transcriptomic changes in TRIP13-deficient MOLM-13 leukemia cells
Listed in NCBI GEO
We performed RNA-seq on MOLM-13 acute myeloid leukemia cells with TRIP13 knockdown to investigate the transcriptomic changes associated with this cancer-testis gene.
Description
TRIP13 is essential for AML progression but dispensable for normal hematopoiesis. Its activation reprograms cellular metabolism from glycolysis to oxidative phosphorylation, enhances fatty acid oxidation, and confers drug resistance.
Mechanistically, TRIP13 localizes to mitochondria, interacts with apoptosis-inducing factor (AIF), and reduces apoptotic priming. Disruption of the TRIP13-AIF interaction suppresses OXPHOS and reverses drug resistance.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE308nnn/GSE308030 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE308030 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1328614 ncbi.nlm.nih.gov/bioproject/PRJNA1328614 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE308030 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |