Omics · study · 2026
Targeting ABL kinases to overcome melanoma immune evasion during MAPKi resistance
Listed in NCBI GEO
We utilized single-cell sequencing to determine the mechanism by which the ABL1/2 inhibitor, nilotinib, prevents the onset of BRAF/MEK inhibitor resistance.
Description
Mice harboring mouse melanomas were treated with BRAF/MEK inhibitors or BRAF/MEK inhibitors plus nilotinib for 4 days, and the resulting tumors were subjected to single-cell RNA-sequencing in order to assess changes in the melanoma and immune populations.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE325nnn/GSE325262 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE325262 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1439323 ncbi.nlm.nih.gov/bioproject/PRJNA1439323 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Sequencing 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE325262 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |