Omics · study · 2026
TRRAP enables MMB-dependent mitotic transcription and determines sensitivity to CHK1 inhibition
Listed in NCBI GEO
The B-MYB-MuvB (MMB) complex is a key regulator of mitotic gene expression and is activated upon inhibition of the ATR-CHK1 pathway, resulting in premature mitotic entry, replication catastrophe, and cell death.
Description
Here we identify the transcriptional co-factor TRRAP as a critical regulator of MMB-dependent mitotic transcription. TRRAP physically interacts with B-MYB and is required for the expression of MMB target genes during both normal G2/M progression and CHK1-inhibitor-induced premature mitosis.
These results identify TRRAP as a critical chromatin co-factor for MMB-driven mitotic transcription, linking chromatin regulation to checkpoint sensitivity and highlighting a potential vulnerability in cancer cells.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE318nnn/GSE318655 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE318655 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1419729 ncbi.nlm.nih.gov/bioproject/PRJNA1419729 ↗
project · from NCBI GEO
- PubMed 42731029 pubmed.ncbi.nlm.nih.gov/42731029 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Genome binding/occupancy profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE318655 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[method].geo_series_type:genome-binding-occupancy-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |