Dissecting the cell autonomous and non-autonomous effects of DNMT1 deletion in PV interneurons

Disruptions in these processes contribute to the pathophysiology of several neuropsychiatric disorders. Parvalbumin-positive (PV) interneurons play a key role in regulating cortical excitability and synchronization, making them central to network stability and cognitive function.

To better understand the contribution of epigenetic regulation to these processes, we investigated the role of DNA methyltransferase 1 (DNMT1) in PV interneurons. By selectively deleting Dnmt1 in this population, we aimed to uncover how DNMT1 influences neuronal function, network activity, and mechanisms underlying neuropsychiatric dysfunction.