Supplementary file 1_Exploratory secondary analysis of published aggregate growth and metabolic data in children born small for gestational age treated with growth hormone.docx

Purpose<p>To describe published annual growth and metabolic summaries for children born small for gestational age (SGA) treated with growth hormone and to define the limits of inference from aggregate registry data.</p>Methods<p>We conducted an exploratory secondary analysis of published aggregate means, standard deviations, and outcome-specific sample sizes from baseline through year 5 in the SGA subgroup of the Korean LG Growth Study, with up to 318 children represented at baseline.

Primary reporting was descriptive and included annual values, changes from baseline, and measurement availability. Exploratory slope models were retained only as supplementary sensitivity analyses. The published aggregate LGS summaries available for the present secondary analysis did not include longitudinal blood-pressure measurements or cardiovascular-event records.</p>Results<p>Height SDS was −2.38 at baseline and −0.76 at year 5, weight SDS was −2.21 and −0.84, and BMI SDS was −0.93 and −0.64.