scRNAseq Dataset of lungs from WT and Clec1a KO mice following primary or secondary E. coli lung infection

Sepsis exhibits phases of enhanced inflammation, alternating with immune suppression. Sepsis-induced immunosuppression is characterized by a deep remodelling of the myeloid immune compartment, leaving patients vulnerable to more severe forms of secondary infections.

Pattern Recognition Receptors (PRRs), such as the C Type Lectin Receptors (CLRs) family, are able to respond to a wide variety of endogenous and exogenous ligands, modulating a plethora of innate responses. We previously described the CLR CLEC-1, as a receptor of necrotic cells expressed by myeloid cells such as conventional Dendritic Cells type I (cDC1), and able to limit antigen presentation and downstream T cell response.