Omics · study · 2026
Harnessing the Innate Tropism of Migratory Interneuron Precursors as a Neuron-Based Therapeutic Platform to Treat Glioblastoma
Listed in NCBI GEO
We found that transplanted post-mitotic Migratory Inhibitory Interneuron Precursors (MIPs), which are currently in clinical trial for refractory epilepsy, are chemoattracted to glioblastoma and can be modified to deliver therapeutic proteins that greatly enhance survival of xenografted mice.
Description
Engrafted MIPs position themselves at the tumor-brain interface in multiple models of HGG and other brain tumors. We conclude that MIPs can become neuron-based platform for localized, sustained anti-tumor therapy.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE316nnn/GSE316559 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE316559 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1403386 ncbi.nlm.nih.gov/bioproject/PRJNA1403386 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE316559 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |