Omics · study · 2026
Chromosome 5q deletion drives evolution to aneuploidy in an iPSC model of complex karyotype leukemia
Listed in NCBI GEO
Aneuploidy is a hallmark of a unique group of high-risk myeloid malignancies including acute myeloid leukemias (AML), known as AML with complex karyotype (AML-CK).
Description
AML-CK is nearly universally associated with TP53 mutations and deletions on the long arm of chromosome 5 (del(5q)), however, the drivers and trajectories of AML-CK evolution have not been established. We performed single cell transcriptomics on iPSC based hematopoietic progenitor cell model of TP53 mutant/TP53 mutant + del5q driven to CK.
Comparisons were performed between 2 AML-CK primary patient samples (R332, RO20518) and 2 isolated del5q MDS parient samples (AGC, TWN).
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE282nnn/GSE282370 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE282370 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1188460 ncbi.nlm.nih.gov/bioproject/PRJNA1188460 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE282370 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |