Orally administrable barrier selective nanoparticle for managing hyperlipidemia by maintaining extra and intracellular cholesterol homeostasis and reducing reactive oxygen species: Aorta samples

CAD is caused by atherosclerotic plaques in blood vessels supplying blood, oxygen and nutrients to the heart tissue. These plaques are buildups of oxidized lipoproteins in the arterial walls, which can eventually lead to the occlusion of blood vessels resulting in heart attack or stroke.

Here, we report the development of a therapeutic lipid nanoparticle (NP) mimicking high density lipoproteins (HDL), which can clear the plaque build-up in the arteries, while also treating the root cause of the plaque build-up – dysfunction in the endothelial cells of the blood vessel. Our lipid NP contains the natural anti-oxidant coenzyme Q10 (CoQ10) to alleviate the reactive oxygen species (ROS) which cause endothelial dysfunction in the blood vessels.