JNKinhibitors for the treatment of inflammation and endometriosis [stroma]

In addition to causing chronic pain, and inflammation, women with endometriosis experience high rates of infertility, migraine, inflammatory bowel disease and autoimmune conditions. In this study, the efficacy of newly developed inhibitors of the c-Jun N-terminal kinases (JNK) were tested as therapeutics for endometriosis.

Using state-of-the-art DNA encoded library screens, JNK inhibitors CDD-2728 and CDD-3013, with high specificity and efficacy were identified and tested in in vitro models of endometriosis. The ability of the inhibitors to decrease inflammation-related gene expression were evaluated in immortalized cell models of endometriosis, 12Z cells, and in primary derived endometriotic stromal cells from patients with the disease.