Omics · study · 2026
A temporal single-nucleus atlas of the hippocampus in temporal lobe epilepsy mice unveils neuroprotective IGF1+ microglia
Listed in NCBI GEO
Epilepsy is a complex chronic disease characterized by intricate interactions between neurons and various types of glial cells during its pathogenesis.
Description
Understanding the molecular sequence of events underlying epilepsy onset and progression is critical for identifying molecular and cellular targets for therapeutic development. In this study, we aimed to reveal the dynamic cell-type-specific responses in TLE hippocampal tissue following KA induction, and identify cellular and molecular mechanisms that either promote or restrict epileptic seizures.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE298nnn/GSE298522 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE298522 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1269606 ncbi.nlm.nih.gov/bioproject/PRJNA1269606 ↗
project · from NCBI GEO
- PubMed 42210782 pubmed.ncbi.nlm.nih.gov/42210782 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Disease 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE298522 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |