Omics · study · 2026
Transcriptome analysis of circSmad5 knockdown in immortalized hair follicle stem cells (iHFSC2)
Listed in NCBI GEO
To investigate the role ofcircSmad5 in hair follicle stem cells (HFSCs), we performed RNA-seq on iHFSC2 cells with circSmad5 knockdown (shcircSmad5) versus empty vector control.
Description
Knockdown of circSmad5 increased hair count in a hair reconstitution model and activated Wnt/β-catenin and Mrs/Erk signaling pathways. This study provides transcriptomic insights into how circSmad5 regulates HFSC stemness and differentiation.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE334nnn/GSE334860 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE334860 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1476637 ncbi.nlm.nih.gov/bioproject/PRJNA1476637 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE334860 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |