Excel · study · 2026
Degradation of AGO2 by TRIM25 drives cancer progression and chemotherapy resistance
Listed in NCBI GEO
AGO2, as a key member of the RISC complex, is underexpressed in a variety of tumor cells.
Description
It is shown that the E3 ligase TRIM25 is highly expressed in a variety of tumor cells and mediates the degradation of the ubiquitin-proteasome pathway of AGO2. This effect of TRIM25 on AGO2 promotes tumor progression and resistance of tumor cells to chemotherapeutic agents.
The specific mechanism is that TRIM25 regulates the level of miR-148b-5p in cells through AGO2, and then regulates the downstream ABCC1. Based on the above results, targeting miR-148b-5p provides a new strategy for the treatment of tumors.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE290nnn/GSE290308 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE290308 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1227454 ncbi.nlm.nih.gov/bioproject/PRJNA1227454 ↗
project · from NCBI GEO
- PubMed 42062253 pubmed.ncbi.nlm.nih.gov/42062253 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens · Non-coding RNA profiling by high throughput sequencing
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE290308 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[method].geo_series_type:non-coding-rna-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |