Excel · study · 2026
Adipokine Adissp as a potential therapeutic agent for diabetes and cardiometabolic diseases
Listed in NCBI GEO
Adipokine Adissp simultaneously promotes glucose disposal and energy expenditure in adipose tissue.
Description
Treatment with recombinant Adissp (rAdissp) protein normalizes hyperglycemia and provides pleiotropic cardiometabolic benefits in diabetic and obese mice, primarily through its actions in white adipose tissue. RNA-seq analysis of inguinal white fat reveals that rAdissp activates a comprehensive thermogenic program characterized by enhanced mitochondrial metabolism, Ucp1-mediated uncoupling, glycolysis, and fatty acid futile cycling.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE302nnn/GSE302416 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE302416 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1290367 ncbi.nlm.nih.gov/bioproject/PRJNA1290367 ↗
project · from NCBI GEO
- PubMed 42030391 pubmed.ncbi.nlm.nih.gov/42030391 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE302416 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |