Omics · study · 2026
Bulk RNA-seq of alveolar type II epithelial cells from wild-type and Cry1/2 double-knockout mice with or without Nobiletin treatment.
Listed in NCBI GEO
Chronic obstructive pulmonary disease (COPD) is a progressive inflammatory lung disease characterized by alveolar destruction and impaired tissue repair.
Description
While circadian disruption has been linked to COPD pathogenesis, the specific molecular mechanisms remain unclear. Here, we isolated primary alveolar epithelial transcriptional profiles in WT, Cry1/2-deficient epithelial cells, as well as in epithelial cells from Cry1/2-deficient mice fed Nobiletin chow.
These studies will help identify key mediators of CRY1/2 as critical circadian regulators that maintain lung structure.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE313nnn/GSE313683 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE313683 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1381336 ncbi.nlm.nih.gov/bioproject/PRJNA1381336 ↗
project · from NCBI GEO
- PubMed 42239331 pubmed.ncbi.nlm.nih.gov/42239331 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Disease 75% · RNA sequencing 65%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE313683 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |