Excel · study · 2026
Consequences of reactive astrogliosis in vivo II
Listed in NCBI GEO
To investigate how molecularly induced reactive astrogliosis (MiRA) affects regional differences among astrocytes, we used a combination of AAV PHP.eB CAG-flex-Rpl22 and AAV PHP.eB GfaABC1D-Cre-4X6T.
Description
We then performed RNA sequencing to examine the transcriptomic profiles of astrocytes isolated from the striatum, hippocampus, and prefrontal cortex in both control and MiRA mice at 4 weeks and 10 weeks post AAV injection.
Our analyses revealed that while MiRA triggers a core set of differentially expressed genes, the inherent regional heterogeneity among astrocytes is largely preserved.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE305nnn/GSE305391 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE305391 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1305449 ncbi.nlm.nih.gov/bioproject/PRJNA1305449 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE305391 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |