Data · dataset · 2026
Data and code for mapping human nutrient-overload programs onto cell states across MASLD progression
Listed in Teesside University Research Data Repository
Description
This dataset contains the study-generated derived data, frozen analytical resources, publication source data, quality-control outputs, audit materials, and versioned R code supporting an integrative public-data study of human nutrient-overload programs across metabolic dysfunction-associated steatotic liver disease (MASLD). The core analytical framework links four public omics resources with distinct evidentiary roles.
GSE200418 was used as a direct human precision-cut liver slice perturbation anchor for deriving nutrient-response programs. GSE202379 provided donor-aware single-nucleus RNA-sequencing data for mapping these frozen programs across human MASLD cell types and cross-sectional disease states, with donors rather than nuclei or tissue specimens treated as the independent biological units. PXD051911 provided hierarchical same-study multicompartment human proteomic support.
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GSE312698 provided a bounded, panel-restricted, FOV/reconstructed-specimen-level descriptive spatial projection in human liver CosMx data. The release includes ranked programs and directional gene sets, identifier harmonization resources, donor-aware cross-layer results, proteomic evidence summaries, bounded spatial-projection outputs, publication figures and tables with source data, reproducibility and quality-control records, and the retained analysis code chain.
Primary repository data are not redistributed. They should be obtained directly from NCBI GEO and ProteomeXchange/PRIDE under accession numbers GSE200418, GSE202379, GSE312698, and PXD051911. Controlled-access materials are not included.
The data support cross-dataset correspondence and orthogonal consistency analyses. They should not be interpreted as evidence of longitudinal disease progression, dietary causality, therapeutic efficacy, or an optimal intervention window.
Links
Where it is published
- DOI doi.org/10.17632/5f78c3yz6n.1 ↗
DOI / persistent id · from researchdata tees ac uk
Catalogue records · 1
- OAI-PMH record data.mendeley.com/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Adata… ↗
metadata API · from researchdata tees ac uk
Topics
- From keywords
- Earth & Environmental Science · Genomics · Life Sciences · Mass spectrometry
- Inferred from text
- Disease 75% · Longitudinal study 65%
Provenance · 1 source records, 11 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| Teesside University Research Data Repository | oai:data.mendeley.com/5f78c3yz6n.1 | 15 h ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · researchdata tees ac uk | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].anzsrc:field:310509 | mapping · researchdata tees ac uk | vocabulary-mapper@1.0.0 | keywords['Genomics'] |
| concepts[field].local:field:earth-environmental | mapping · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| concepts[method].local:method:longitudinal-study | enrichment · researchdata tees ac uk | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[modality].local:modality:mass-spectrometry | mapping · researchdata tees ac uk | vocabulary-mapper@1.0.0 | keywords['Proteomics'] |
| description | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | /metadata/dc/description |
| license | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | /metadata/dc/rights |
| publication_date | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | |
| title | source · researchdata tees ac uk | connector:researchdata_tees_ac_uk@1.0.0 | /metadata/dc/title |