Excel · study · 2026
Differentially expressed genes (DEGs) in the corneas of Muc13 KO mice versus wild-type controls
Listed in NCBI GEO
The mucosal barrier protein MUC13 plays a critical role in maintaining epithelial homeostasis, yet its function remains poorly defined.
Description
In this study, we utilized a combination of genetic knockout models and transcriptomic profiling to elucidate the impact of MUC13 deficiency on tissue responses. Comparative analysis of corneal tissues from 6-week-old male Muc13-knockout (C57BL/6 background) and wild-type (WT) male mice revealed profound transcriptional perturbations in Muc13-/- mouse cornea.
RNA sequencing identified a distinct repertoire of differentially expressed genes (DEGs) associated with the loss of MUC13. These findings demonstrate that MUC13 is a pivotal modulator of the epithelial barrier.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE335nnn/GSE335461 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE335461 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1478582 ncbi.nlm.nih.gov/bioproject/PRJNA1478582 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE335461 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |