Integrating Single-Cell and Macroscopic Transcriptomics to Decode Transcriptional and Immune Microenvironment Remodeling Associated with Extravillous Trophoblast Invasion Arrest in Severe Preeclampsia

The core pathological features of this condition involve shallow invasion of extravillous trophoblasts and defective vascular remodeling at the maternal-fetal interface during early pregnancy. Despite its clinical importance, the transcriptional reprogramming and dynamic cell-to-cell communication at single-cell resolution in severe preeclampsia remain insufficiently explored.

This study aims to delineate the lineage shifts of extravillous trophoblasts and the associated immune microenvironment crosstalk