Omics · study · 2026
RNA-Seq Analysis of Fibroblast-Like Synoviocytes Treated With Lutein in a Rheumatoid Arthritis Context
Listed in NCBI GEO
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial inflammation and progressive joint destruction.
Description
Although lutein is known for its antioxidant and anti-inflammatory properties, its effects on gene expression in RA-associated synoviocytes remain unclear. In this study, we performed RNA sequencing to investigate transcriptomic changes in fibroblast-like synoviocytes (FLS) treated with lutein.
Differentially expressed genes were identified and analyzed using Gene Set Enrichment Analysis (GSEA) and Ingenuity Pathway Analysis (IPA) to explore relevant biological processes and molecular networks. The results revealed that lutein treatment altered the expression of genes involved in extracellular matrix remodeling and inflammation. Enrichment analyses suggested modulation of signaling pathways associated with RA pathogenesis.
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These transcriptomic findings provide insights into the potential molecular effects of lutein on RA-related synovial cells and serve as a basis for further functional investigation.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE301nnn/GSE301891 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE301891 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1287697 ncbi.nlm.nih.gov/bioproject/PRJNA1287697 ↗
project · from NCBI GEO
- PubMed 42328127 pubmed.ncbi.nlm.nih.gov/42328127 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Disease 75% · RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE301891 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |