Omics · dataset · 2026
Molecular and genetic characterisation of contralateral breast cancer (CBC): opportunities for personalised surgery
Listed in ZivaHub and Deakin Research Online and DMU Figshare and UCL Research Data Repository — shown once because both records carry DOI 10.17034/32631402.v1
This thesis outlines a molecular epidemiology and genetic sequencing study carried out to investigate the relationship between primary and contralateral breast cancers (CBCs).
Description
Additionally, given the known risk factors for CBC development of young age at primary diagnosis and significant family history, the genetic predisposition of the CBC cohort was assessed.<br><br>Firstly, the population of women in Northern Ireland that have developed a CBC between 1993 ad 2016 was identified through the Northern Ireland Cancer Registry.
The data obtained from this cohort was investigated for survival and prognostic factors in order to better understand CBC at a clinical and population level in Northern Ireland.<br><br>Next, the archival tumours of these patients were obtained so that somatic and germline DNA could be extracted to carry out a next generation sequencing study. This study utilised a customised target panel of genes comprising the most commonly mutated genes observed in breast cancers and all known breast cancer susceptibility genes.
Read the rest (1 more)
The data obtained from this NGS study helped to address the two main aims - assess the genetic relationship between primary and contralateral tumours within the CBC cohort and assess the germline breast cancer predisposition of the women in the cohort.
Links
Where it is published
- DOI doi.org/10.17034/32631402.v1 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Medicine & Health · Medicine & Health · Medicine & Health · Medicine & Health · Sequencing · Sequencing · Sequencing · Sequencing
- Inferred from text
- Cancer 75% · Oncology and carcinogenesis 74%
Provenance · 4 source records, 18 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/32631402 | 13 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/32631402 | 13 d ago | JSON v1 |
| DMU Figshare | oai:figshare.com:article/32631402 | 13 d ago | JSON v1 |
| UCL Research Data Repository | oai:figshare.com:article/32631402 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[disease].local:disease:cancer | enrichment · zivahub uct ac za | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].anzsrc:group:3211 | enrichment · zivahub uct ac za | taxonomy-embedding@1.1.0 | title+keywords+description (74%) |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[modality].local:modality:sequencing | mapping · dro deakin edu au | vocabulary-mapper@1.0.0 | keywords['sequencing'] |
| concepts[modality].local:modality:sequencing | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['sequencing'] |
| concepts[modality].local:modality:sequencing | mapping · figshare dmu ac uk | vocabulary-mapper@1.0.0 | keywords['sequencing'] |
| concepts[modality].local:modality:sequencing | mapping · rdr ucl ac uk | vocabulary-mapper@1.0.0 | keywords['sequencing'] |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license_text | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |