Constarium
← Search

Omics · study · 2026

Bulk RNA-seq analysis of wild-type and LRRC8A knockout primary mouse aortic vascular smooth muscle cells

Listed in NCBI GEO

LRRC8A-containing volume-regulated anion channels regulate redox signaling, inflammatory transcriptional activity, metabolism, and senescence in vascular smooth muscle cells.

Description

To define transcriptional changes caused by LRRC8A deletion, bulk RNA sequencing was performed on primary cultured mouse aortic vascular smooth muscle cells isolated from wild-type and smooth muscle-specific LRRC8A knockout mice. The dataset was used to identify genotype-dependent differences in inflammatory, hypoxia-responsive, metabolic, and stress-related gene-expression pathways.

Links

Get the data

Where it is published

Documentation and papers

Topics

Stated by source
Expression profiling by high throughput sequencing · Mus musculus
From keywords
Life Sciences
Inferred from text
RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
SourceKeyLast seenRaw
NCBI GEOGSE33287912 d agoJSON v1
FieldAssertionExtractorEvidence
access_levelsource · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[field].local:field:life-sciencesmapping · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencingsource · NCBI GEOconnector:ncbi_geo@1.0.0/gdstype
concepts[modality].local:modality:rna-seqenrichment · NCBI GEOkeyword-concept-rules@1.0.0title+description (75%)
concepts[modality].local:modality:sequencingenrichment · NCBI GEOkeyword-concept-rules@1.0.0title+description (75%)
concepts[organism].NCBITaxon:10090source · NCBI GEOconnector:ncbi_geo@1.0.0/taxon
descriptionsource · NCBI GEOconnector:ncbi_geo@1.0.0/summary
publication_datesource · NCBI GEOconnector:ncbi_geo@1.0.0
titlesource · NCBI GEOconnector:ncbi_geo@1.0.0/title