Transcriptomic Profiling of SLC and ABC Transporters in the Human Term Placenta

Xenobiotic, vitamin, sugar, and choline transporters were also represented, and 11% were orphan transporters. Notably, intracellular SLCs localized to the ER/Golgi, mitochondria, and lysosome comprised 37% of the top expressed SLCs. Thirty-seven ABC transcripts were detected in the intervillous region, primarily involved in xenobiotic and lipid transport.

Compared with the intervillous region, 1,676 genes—including 32 SLCs and 2 ABC transporters—were differentially expressed in the decidual region. Although 79 genes in the intervillous region and 117 genes in the decidual region exhibited sexually dimorphic expression, none were SLC transporters. Together, these findings provide a comprehensive transcriptomic map of SLC and ABC transporters in the term human placenta by fetal sex and tissue regions.