Omics · study · 2026
RNA-Seq Profiling of Kidney Responses in Wild-Type and Angpt2 Knockout Mice Following a 3-Week Adenine Diet
Listed in NCBI GEO
Chronic kidney disease (CKD) is characterized by progressive tubulointerstitial injury, which plays a critical role in renal dysfunction.
Description
Angiopoietin-2 (Angpt2) is implicated in vascular and inflammatory processes, but its role in CKD remains unclear. In this study, we performed RNA-seq to analyze gene expression differences in the kidneys of wild-type and Angpt2 knockout mice after a 3-week adenine diet, a well-established model of tubulointerstitial injury.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE300nnn/GSE300746 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE300746 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1281200 ncbi.nlm.nih.gov/bioproject/PRJNA1281200 ↗
project · from NCBI GEO
- PubMed 41979897 pubmed.ncbi.nlm.nih.gov/41979897 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Disease 75% · RNA sequencing 65%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE300746 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |