Omics · study · 2026
Transcriptomic profiling of the therapeutic effects of Huashibaidu Granules (HBG) on bleomycin-induced pulmonary fibrosis in mice.
Listed in NCBI GEO
Pulmonary fibrosis is a chronic and progressive interstitial lung disease characterized by excessive extracellular matrix deposition.
Description
Huashibaidu Granules (HBG), a traditional Chinese medicine formula, has demonstrated clinical efficacy in treating inflammatory lung diseases. In this study, we aimed to investigate the molecular mechanisms of HBG in alleviating pulmonary fibrosis.
We established a bleomycin-induced pulmonary fibrosis mouse model and administered HBG at different doses. Total RNA was extracted from lung tissues for high-throughput RNA sequencing. Our results provide a comprehensive transcriptomic landscape of HBG’s intervention, highlighting its role in regulating key signaling pathways (such as TGF-β/Smad and PI3K-Akt) and macrophage polarization.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE329nnn/GSE329966 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE329966 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1462283 ncbi.nlm.nih.gov/bioproject/PRJNA1462283 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Disease 75% · RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE329966 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |