Omics · study · 2026
Transcriptomic profiling of endothelial cells with altered cholesterol
Listed in NCBI GEO
Cholesterol has been associated with the regulation of angiogenesis in endothelial cells of the central nervous system, but the mechanisms responsible for this regulation have not been explored at the genome level.
Description
Here, we performed transcriptomic profiling on the isolated brain vasculature of mouse embryos lacking two main cholesterol transporters, ABCA1 and SR-B1. We complemented these data with transcriptomic profiles of a cell line representing brain endothelial cells and chicken chorioallantoic membranes treated with methyl-β-cyclodextrin, which removes cholesterol from cells.
We observed changes in the expression of many angiogenic genes upon modulation of cellular cholesterol, indicating coupling of cholesterol metabolism and angiogenesis in CNS endothelial cells.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE310nnn/GSE310310 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE310310 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1365739 ncbi.nlm.nih.gov/bioproject/PRJNA1365739 ↗
project · from NCBI GEO
- PubMed 42099390 pubmed.ncbi.nlm.nih.gov/42099390 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Gallus gallus · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE310310 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| concepts[organism].NCBITaxon:9031 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |