Excel · study · 2026
Transcriptomic profiling reveals AVP-responsive molecular changes in GT1-7 GnRH neurons
Listed in NCBI GEO
Arginine vasopressin (AVP) has been implicated in the regulation of gonadotropin-releasing hormone (GnRH) neurons, but the transcriptomic mechanisms underlying this effect remain unclear.
Description
In this study, GT1-7 GnRH neuronal cells were treated with AVP and analyzed by bulk RNA sequencing. Compared with control cells, AVP treatment induced broad transcriptional changes, with 1,094 differentially expressed genes identified, including 549 up-regulated and 545 down-regulated genes.
Functional enrichment analysis highlighted AVP-associated changes in signaling pathways related to TNF signaling, PI3K-Akt signaling, MAPK signaling, cAMP signaling, axon guidance, and Wnt signaling. These data provide a transcriptomic resource for understanding AVP-responsive molecular programs in GT1-7 GnRH neurons.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE329nnn/GSE329856 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE329856 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1461951 ncbi.nlm.nih.gov/bioproject/PRJNA1461951 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE329856 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |