Distinct chromatin accessibility landscape of IgA, IgG, and IgM ASC [ASC.ATACseq]

Despite studies defining the transcriptional programs of selected ASC isotypes, specific mechanisms underlying isotype specific gene regulation are largely unaddressed. Here, we performed ATAC-seq on surface-sorted IgM, IgG, and IgA ASCs isolated from the spleens and mediastinal lymph nodes of mice following influenza infection.

We observed isotype-specific chromatin accessibility patterns that indicate distinct functions underpin ASC of each isotype.