Omics · study · 2026
Effects of HDAC gene knockdowns in human stem cell derived cardiomyocytes
Listed in NCBI GEO
Histone deacetylases (HDACs) play a major role in a wide range of cellular and developmental processes, often as master regulators of gene transcription.
Description
These epigenetic modifiers, which include eleven canonical HDACs and seven sirtuins (SIRTs), are commonly studied in cancer, especially by using nonselective HDAC inhibitor drugs. However, HDACs and SIRTs are also thought to be influential in cardiac function and pathology, yet the specific roles of individual HDACs have not been robustly probed in cardiomyocytes.
In this study, we report the transcriptomic effects of individual HDAC/SIRT knockdowns in human induced pluripotent stem cell derived cardiomyocytes.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE309nnn/GSE309350 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE309350 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1335217 ncbi.nlm.nih.gov/bioproject/PRJNA1335217 ↗
project · from NCBI GEO
- PubMed 41648544 pubmed.ncbi.nlm.nih.gov/41648544 ↗
publication · from NCBI GEO
- PubMed 42644057 pubmed.ncbi.nlm.nih.gov/42644057 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE309350 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[anatomy].local:anatomy:heart | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |