Table · dataset · 2026
Data Sheet 1_Clinical characteristics and immunotherapy in Chinese patients with Merkel cell carcinoma: a retrospective analysis.docx
Listed in figshare and Loughborough Research Repository — shown once because both records carry DOI 10.3389/fonc.2026.1948121.s001
Purpose<p>Merkel cell carcinoma (MCC) is a rare but highly aggressive cutaneous malignancy with limited epidemiological and therapeutic data in Asian populations.
Description
While immunotherapy works in Western patients, its efficacy in Chinese MCC patients remains unexplored.</p>Methods<p>We retrospectively analyzed 40 histologically confirmed MCC cases treated at our institution between November 2011 to November 2024. Sixteen patients with complete records underwent detailed analysis of demographics, treatments, and responses.</p>Results<p>The cohort included 25 female and 15 male patients (median age 71 years, range 25-91).
Of the 16 patients with detailed information, 15 (94%) patients underwent extensive resection while 1 did not. Among surgical patients, 1 (7%) patient operative area received postoperative adjuvant radiotherapy, and 2 (13%) had additional lymph node dissection. Immunohistochemical analysis showed that out of 10 evaluable patients, 8 (80%) were MCPyV positive and 3 (30%) were PD-L1 positive.
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Among the patients receiving systemic treatment, four were administered Pembrolizumab at a dose of 200 mg every three weeks. Remarkably, three of these patients (75%) achieved a complete response (CR) by radiographic evaluation, with two of the treated specimens showed no residual malignant cells detected in post-treatment biopsy specimens. The treatment was well-tolerated, with no grade 3 or higher adverse events reported during the observation period.</p>Conclusion<p>This study describes MCC characteristics in Chinese patients, with preliminary indications of female predominance and favorable immunotherapy responses.
The findings highlight the need for standardized treatment approaches.</p>
Links
Where it is published
- DOI doi.org/10.3389/fonc.2026.1948121.s001 ↗
DOI / persistent id · from figshare com
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from figshare com
Topics
- From keywords
- Astronomy & Astrophysics · Chemistry · Chemistry · Computer Science & AI · Computer Science & AI · Earth & Environmental Science · Earth & Environmental Science · Economics & Finance · Economics & Finance · Engineering · Engineering · Humanities · Humanities · Life Sciences · Life Sciences · Materials Science · Mathematics & Statistics · Medicine & Health · Medicine & Health · Ocean & Atmospheric Science · Psychology & Behavioral Science · Social Science · Social Science
- Inferred from text
- Oncology and carcinogenesis 70%
Provenance · 2 source records, 29 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| figshare | oai:figshare.com:article/33961573 | 11 d ago | JSON v1 |
| Loughborough Research Repository | oai:figshare.com:article/33961573 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].anzsrc:group:3211 | enrichment · figshare com | taxonomy-embedding@1.0.0 | title+keywords+description (70%) |
| concepts[field].local:field:astronomy | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:computer-science-ai | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:computer-science-ai | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:economics-finance | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:economics-finance | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:engineering | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:engineering | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:humanities | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:humanities | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:materials-science | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:mathematics-statistics | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:ocean-atmospheric | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:psychology-behavioral | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:social-science | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:social-science | mapping · figshare com | connector:figshare_com@1.0.0 | |
| description | source · figshare com | connector:figshare_com@1.0.0 | /metadata/dc/description |
| license | source · figshare com | connector:figshare_com@1.0.0 | /metadata/dc/rights |
| publication_date | source · figshare com | connector:figshare_com@1.0.0 | |
| title | source · figshare com | connector:figshare_com@1.0.0 | /metadata/dc/title |