Text · study · 2026
LncRNA-NFYB axis drives immune suppression to promote HCC progression by a positive feedback
Listed in NCBI GEO
Metastases are the main cause of cancer mortality, but the mechanisms underlying aggressive progression remain poorly understood.
Description
Genome-wide characterization of chromatin accessibility reveals the opening of large numbers of distal regulatory elements across the genome during metastatic progression, which correlate with NFYB. Further, hepatocellular LINC01137 mitigates antitumour T cell responses by expanding MDSC to promote HCC metastasis via stabilizing NFYB to recruit SMYD3 to upregulate IL-1β, CXCL2 and CCL20.
Mechanistically, LINC01137 recruits SMYD3 to increase the occupancy of H3K4me3 on promoters of IL-1β, CXCL2 and CCL20 by NFYB. Importantly, LINC01137 transcription is activated by NFYB/KAT2B complex in a feed-forward loop. Clinically, Concordant overexpression of LINC01137-NFYB and MDSC markers positively correlates with poorer survival.
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Notably, IL-1β inhibitor enhances the blockade efficacy of PD-L1 in LINC01137-overexpressing HCC. Our results delineate an immunosuppressive mechanism of LINC01137-NFYB signalling during HCC progression and supply a proof for the concept of engineering microenvironment in HCC immunotherapy.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE154nnn/GSE154509 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE154509 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA646506 ncbi.nlm.nih.gov/bioproject/PRJNA646506 ↗
project · from NCBI GEO
- PubMed 42368565 pubmed.ncbi.nlm.nih.gov/42368565 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Homo sapiens · Other
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE154509 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:other | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |