Omics · study · 2026
A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture
Listed in NCBI GEO
This dataset contains the RNA-seq data associated with a CRISPR/Cas9 study for which the screen results (sgRNA reads) are included in the GEO record GSE15547.
Description
Specifically, this dataset contains the RNA-seq results used to assess absolute gene expression in Nalm-6 cells, results for 3 PPP3CA knockout polulations, 3 PPP3R1 knockout populations, one FK-506 (tacrolimus) treated population and ERCC spike-in experiments on PABIR1 (formerly FAM122A) knockout cells, each with their own wild type and/or DMSO-treated control samples.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE316nnn/GSE316956 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE316956 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1405595 ncbi.nlm.nih.gov/bioproject/PRJNA1405595 ↗
project · from NCBI GEO
- PubMed 41659671 pubmed.ncbi.nlm.nih.gov/41659671 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65%
Related
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE316956 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |