Excel · study · 2026
Transcriptomic profiling of fibroblasts and induced mesenchymal stem cells derived from patients with Legg-Calve-Perthes disease
Listed in NCBI GEO
Legg-Calve-Perthes disease (LCPD) is a pediatric osteonecrotic disorder characterized by ischemic necrosis of the femoral head.
Description
To investigate disease-associated molecular alterations, bulk RNA sequencing was performed using dermal fibroblasts and induced mesenchymal stem cells (iMSCs) derived from healthy donors and patients with LCPD. Differential expression analysis identified dysregulation of developmental, extracellular matrix, inflammatory, and Wnt signaling pathways.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE342nnn/GSE342619 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE342619 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1508653 ncbi.nlm.nih.gov/bioproject/PRJNA1508653 ↗
project · from NCBI GEO
- PubMed 42706650 pubmed.ncbi.nlm.nih.gov/42706650 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Disease 75% · RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE342619 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |