Omics · study · 2026
Engineered cytokine-secreting cells to prevent foreign body response against implants
Listed in NCBI GEO
Foreign body response hinders the long-term functionality of implants such as microencapsulated cell therapies.
Description
To address this issue, we delivered encapsulated engineered cells that secrete targeted cytokines to mitigate fibrosis on microcapsules. Here, we quantify immune profile change due to these encapsulated cytokine-secreting cells in mice.
We identified that IL10 prevents inflammatory response while IL12 impairs the TGF-beta pathway to mitigate fibrosis.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE294nnn/GSE294864 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE294864 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1251884 ncbi.nlm.nih.gov/bioproject/PRJNA1251884 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE294864 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |