Raster · study · 2026
Spatial Transcriptome Profiling Reveals Molecular Features of Invasive Lobular Carcinoma in Breast Cancer.
Listed in NCBI GEO
These samples were collected for spatial transcriptome analysis of invasive lobular carcinoma of the breast (ILC).
Description
We analyzed differences in the molecular profiles of classical ILCs (C-ILCs) and polymorphic ILCs (P-ILCs). We obtained transcriptome data from ● different spots.
The cell type of each spot was inferred from copy number changes and gene expression data of human tumors by SpaCET. There were 11 cell types, with cancer-dominant and CAF-dominant spots accounting for the majority. Analysis of canonical pathways and upstream regulators by IPA indicated that the cell cycle is upregulated in P-ILC cancer-dominant spots than in C-ILC cancer-dominant spots.
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Furthermore, EMT and angiogenesis were upregulated in P-ILC stroma-dominant spots than in C-ILC stroma-dominant spots.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE290nnn/GSE290670 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE290670 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1229510 ncbi.nlm.nih.gov/bioproject/PRJNA1229510 ↗
project · from NCBI GEO
Topics
- Stated by source
- Homo sapiens · Other
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE290670 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:other | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |