Excel · study · 2026
ALDH1 inhibitor, DIMATE, Preserves Immune Function While Inducing Immunogenic Remodelling in AML
Listed in NCBI GEO
DIMATE Preserves Immune Cells in AML Our study provides a comprehensive characterization of the immuno‑pharmacological effects of DIMATE, a selective ALDH1 inhibitor currently evaluated in the First‑in‑Human ODYSSEY trial.
Description
We show that DIMATE preserves the core functions of circulating immune populations—including PBMCs, T cells, NK cells, and phagocytes—while inducing a coordinated pro‑inflammatory and ER‑stress response in AML cells that culminates in the exposure of ecto‑calreticulin, a canonical hallmark of immunogenic cell death (ICD).
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE325nnn/GSE325279 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE325279 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1439368 ncbi.nlm.nih.gov/bioproject/PRJNA1439368 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by array · Homo sapiens
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE325279 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-array | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |