Omics · study · 2026
TPX2 drives cell cycle progression and impairs immune cell communication in lung cancer based on multi-omics evidence
Listed in NCBI GEO
Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality worldwide.
Description
Despite significant advancements in diagnosis and treatment, its mortality rate persists at alarmingly high levels. TPX2, a critical cell cycle regulatory protein, has been reported to exhibit aberrant expression in various malignancies, yet its specific mechanistic role in lung cancer remains poorly understood.
To elucidate the mechanism of TPX2-driven lung cancer and identify its downstream transcriptional targets, we conducted genome-wide RNA sequencing in A549 cells knockdowning TPX2, with comparison to negative control (sh-NC) group.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE333nnn/GSE333209 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE333209 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1470491 ncbi.nlm.nih.gov/bioproject/PRJNA1470491 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75% · RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE333209 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |