Roles of the nuclear receptor corepressor 1 (NCoR1) and the silencing mediator of retinoid and thyroid hormone receptors (SMRT) in the developing brain

Although they are highly homologous and have similar receptor interacting domains, they have different roles in different tissues. Recently, de novo genetic variants in nuclear corepressors were found in pediatric patients with neurodevelopmental disorders.

Thus, we generated novel mouse models to understand the role of NCOR1 and SMRT in the central nervous system. We used the mice with conditional NCoR1 or SMRT (NCoR1lox/lox or SMRTlox/lox) alleles in combination with the mice that express Cre recombinase in a neuronal specific fashion (Snap25-IRES2-cre). First, we performed behavioral tests to assess for any behavioral phenotypes.