Data · study · 2026
Gene expression in HCV-infected Huh-7.5 cells treated with or without tyrosine kinase inhibitors
Listed in NCBI GEO
HCV hijacks host tyrosine kinases to support its life cycle.
Description
Non-receptor kinases such as Abl can interact with viral proteins including NS5A, thereby modulating viral assembly. These findings highlight tyrosine kinases as promising therapeutic targets for antiviral intervention.
We used microarrays to profile the global gene expression changes in HCV-infected Huh-7.5 cells treated with bosutinib or entospletinib compared with control, and identified distinct sets of differentially expressed genes associated with viral regulation.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE305nnn/GSE305769 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE305769 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1307574 ncbi.nlm.nih.gov/bioproject/PRJNA1307574 ↗
project · from NCBI GEO
- PubMed 41478568 pubmed.ncbi.nlm.nih.gov/41478568 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by array · Homo sapiens
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE305769 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-array | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |