Omics · study · 2026
GSK-J4 treatment in ovarian cancer cell lines (ATAC-Seq)
Listed in NCBI GEO
The deregulation of histone methylation profiles has been implicated in the pathogenesis of multiple diseases, including ovarian cancer, on of the most lethal gynaecological malignancies worldwide.
Description
The roles of de-methylases KDM6A/UTX and KDM6B/JDMJD3, generally associated with the maintenance of normal levels of H3K27 methylation, have not been investigated in detail in ovarian cancer, and their functions remain largely unknown.
Here, we used the KDM6A/B targeting drug GSK-J4 to understand the implications of specific histone methylation in ovarian cancer. GSK-J4 triggered different responses including anti-proliferative activity, enhanced apoptotic cell death mechanisms and EMT differentiation, amongst others.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE262nnn/GSE262172 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE262172 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1090516 ncbi.nlm.nih.gov/bioproject/PRJNA1090516 ↗
project · from NCBI GEO
- PubMed 42041165 pubmed.ncbi.nlm.nih.gov/42041165 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Genome binding/occupancy profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE262172 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:genome-binding-occupancy-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |